Article
Deletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice.
Proceedings of the National Academy of Sciences of the United States of America - 20 Mar 2007
Bhatt Apoorva, Fujiwara Nagatoshi, Bhatt Kiranmai, Gurcha Sudagar S, Kremer Laurent, Chen Bing, Chan John, Porcelli Steven A, Kobayashi Kazuo, Besra Gurdyal S, Jacobs William R
Abstract excerpt
Mycobacterium tuberculosis, the causative agent of tuberculosis, has two distinguishing characteristics: its ability to stain acid-fast and its ability to cause long-term latent infections in humans. Although this distinctive staining characteristic has often been attributed to its lipid-rich cell wall, the specific dye-retaining components were not known. Here we report that targeted deletion of kasB, one of two...
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