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Article

Acidification of the osteoclastic resorption compartment provides insight into the coupling of bone formation to bone resorption.

The American journal of pathology - 1 Feb 2005

Karsdal Morten A, Henriksen Kim, Sørensen Mette G, Gram Jeppe, Schaller Sophie, Dziegiel Morten H, Heegaard Anne-Marie, Christophersen Palle, Martin Thomas J, Christiansen Claus, Bollerslev Jens

Abstract excerpt

Patients with defective osteoclastic acidification have increased numbers of osteoclasts, with decreased resorption, but bone formation that remains unchanged. We demonstrate that osteoclast survival is increased when acidification is impaired, and that impairment of acidification results in inhibition of bone resorption without inhibition of bone formation. We investigated the role of acidification in human...

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Identifiers

PMID: 15681830
DOI: 10.1016/S0002-9440(10)62269-9
PMCID: PMC1602325

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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