Article
Differential dropout among SNP genotypes and impacts on association tests.
Human heredity - 1 Jan 2007
Hao Ke, Cawley Simon
Abstract excerpt
BACKGROUND: Current biotechnologies are able to achieve high accuracy and call rates. Concerns are raised on how differential performance on various genotypes may bias association tests. Quantitatively, we define differential dropout rate as the ratio of no-call rate among heterozygotes and homozygotes. METHODS: The hazard ofdifferential dropout is examined for population- and family-based association tests...
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