Differential dropout among SNP genotypes and impacts on association tests.

doi:10.1159/000100480

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Article

Differential dropout among SNP genotypes and impacts on association tests.

Human heredity - 1 Jan 2007

Hao Ke, Cawley Simon

Abstract excerpt

BACKGROUND: Current biotechnologies are able to achieve high accuracy and call rates. Concerns are raised on how differential performance on various genotypes may bias association tests. Quantitatively, we define differential dropout rate as the ratio of no-call rate among heterozygotes and homozygotes. METHODS: The hazard ofdifferential dropout is examined for population- and family-based association tests...

Topics

Case-Control Studies
Gene Frequency
Genotype
Humans
Linear Models
Odds Ratio
Polymorphism, Single Nucleotide
Sample Size

Source

Open in PubMed

Identifiers

PMID: 17347569
DOI: 10.1159/000100480

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