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Extended evaluation of the impact of dropout probability on likelihood ratios calculated in parent-child and full sibling analysis.

Legal medicine (Tokyo, Japan) - 1 May 2026

Watahiki Haruhiko, Shibata Tomofumi, Fukagawa Takashi, Mita Yusuke, Kitayama Tetsushi, Fujii Koji

Abstract excerpt

Kinship analysis using autosomal short tandem repeats enables the use of likelihood ratios (LRs) to evaluate kinship relationships, but allelic dropout in low-quantity or low-quality DNA can bias the results. A model that incorporates dropout probability for kinship analysis has been proposed, but its evaluation remains limited. In this study, we systematically examined LR values under the dropout model in...

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PMID: 42013594
DOI: 10.1016/j.legalmed.2026.102841

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