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Article

Reduced progression of endometrial hyperplasia with oral mTOR inhibition in the Pten heterozygote murine model.

American journal of obstetrics and gynecology - 1 Mar 2007

Milam Michael R, Celestino Joseph, Wu Weiguo, Broaddus Russell R, Schmeler Kathleen M, Slomovitz Brian M, Soliman Pamela T, Gershenson David M, Wang Hong, Ellenson Lora H, Lu Karen H

Abstract excerpt

OBJECTIVE: Phosphatase and tensin homolog (PTEN) mutations are associated with human endometrial cancers, and PTEN heterozygote(+/-) mice have a high rate of endometrial neoplasia. The objective of this study was to evaluate an oral mTOR inhibitor (mTOR-I) on the reduction of endometrial hyperpla...

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Source

Identifiers

PMID: 17346540
DOI: 10.1016/j.ajog.2006.10.872

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17346540-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Reduced progression of endometrial hyperplasia with oral mTOR inhibition in the Pten heterozygote murine model.PMID 17346540Read ↗

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