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Article

Overactive mTOR signaling leads to endometrial hyperplasia in aged women and mice.

Oncotarget - 31 Jan 2017

Bajwa Preety, Nielsen Sarah, Lombard Janine M, Rassam Loui, Nahar Pravin, Rueda Bo R, Wilkinson J Erby, Miller Richard A, Tanwar Pradeep S

Abstract excerpt

During aging, uncontrolled epithelial cell proliferation in the uterus results in endometrial hyperplasia and/or cancer development. The mTOR signaling pathway is one of the major regulators of aging as suppression of this pathway prolongs lifespan in model organisms. Genetic alterations in this pathway via mutations and/or amplifications are often encountered in endometrial cancers. However, the exact...

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Share to Endometrial Hyperplasia
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Epithelial Cells

Share to PTEN Phosphohydrolase

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Share to TOR Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 27980219
DOI: 10.18632/oncotarget.13919
PMCID: PMC5352319

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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