Article
Matrix Metalloproteinase-9 (MMP-9) polymorphisms in patients with cutaneous malignant melanoma.
BMC medical genetics - 8 Mar 2007
Cotignola Javier, Reva Boris, Mitra Nandita, Ishill Nicole, Chuai Shaokun, Patel Ami, Shah Shivang, Vanderbeek Gretchen, Coit Daniel, Busam Klaus, Halpern Allan, Houghton Alan, Sander Chris, Berwick Marianne, Orlow Irene
Abstract excerpt
BACKGROUND: Cutaneous Malignant Melanoma causes over 75% of skin cancer-related deaths, and it is clear that many factors may contribute to the outcome. Matrix Metalloproteinases (MMPs) play an important role in the degradation and remodeling of the extracellular matrix and basement membrane that, in turn, modulate cell division, migration and angiogenesis. Some polymorphisms are known to influence gene...
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