Article
CDKN2A mutations and melanoma risk in the Icelandic population.
Journal of medical genetics - 1 May 2008
Goldstein A M, Stacey S N, Olafsson J H, Jonsson G F, Helgason A, Sulem P, Sigurgeirsson B, Benediktsdottir K R, Thorisdottir K, Ragnarsson R, Kjartansson J, Kostic J, Masson G, Kristjansson K, Gulcher J R, Kong A, Thorsteinsdottir U, Rafnar T, Tucker M A, Stefansson K
Abstract excerpt
BACKGROUND: Germline CDKN2A mutations have been observed in 20-40% of high risk, melanoma prone families; however, little is known about their prevalence in population based series of melanoma cases and controls. METHODS: We resequenced the CDKN2A gene, including the p14ARF variant and promoter regions, in approximately 703 registry ascertained melanoma cases and 691 population based controls from Iceland, a...
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