Article

Genetic and structural evidence links Ca <sup>2+</sup> dysregulation and ATP2B2 to neuropsychiatric illness

2025-08-27

Abstract excerpt

Neuropsychiatric disorders are highly heritable, but the molecular mechanisms linking risk variants to disease remain unclear 1 . Linking genetics to biological mechanisms requires integrating evidence across scales, from sequence variation to gene regulation to protein function. Here we integrate genetic, transcriptomic, and structural evidence to identify dysregulation of neuronal Ca 2+ dynamics as a contribut...

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Literature Corpus work: 4376317f-92fc-5c7b-9f6c-f0e3e12112bf
DOI: 10.1101/2025.08.25.672202

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