Article
Epitope cross-reactivity frequently differs between central and effector memory HIV-specific CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2007
McKinnon Lyle R, Ball T Blake, Wachihi Charles, McLaren Paul J, Waruk Jillian L M, Mao Xiaojuan, Ramdahin Sue, Anzala A Omu, Kamene Jane, Luo Ma, Fowke Keith R, Plummer Francis A
Abstract excerpt
HIV diversity may limit the breadth of vaccine coverage due to epitope sequence differences between strains. Although amino acid substitutions within CD8(+) T cell HIV epitopes can result in complete or partial abrogation of responses, this has primarily been demonstrated in effector CD8(+) T cells. In an HIV-infected Kenyan cohort, we demonstrate that the cross-reactivity of HIV epitope variants differs...
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