MEF2C is a new regulator of the human articular chondrocyte phenotype

Abstract excerpt

MEF2C plays a role in diverse tissues, most notably heart, brain, eyes and developing bones. Here we report for the first time that MEF2C is present and active in the permanent articular cartilage in humans which lines and protects our joints throughout life. We show that MEF2C directly targets cartilage master regulator gene SOX9, and SOX9, in turn, regulates MEF2C in a novel positive feedback loop maintaining hi...

Topics

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• Bone Development
• Cartilage
• Dwarfism
• Histone Deacetylases
• Hypertrophy
• MEF2 Transcription Factors
• Myogenic Regulatory Factors
• Neovascularization, Physiologic

Identifiers and source

Literature Corpus work

2af5fe12-d036-5a5c-9660-b476db1e245b

DOI

10.1101/315630