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Article

Analysis of DNA repair and recombination responses in mouse cells depleted for Brca2 by SiRNA.

DNA repair - 1 Jun 2007

Lee Shauna A, Baker Mark D

Abstract excerpt

The tumor suppressor BRCA2 is considered to play an important role in the maintenance of genome integrity through the repair of DNA lesions by homologous recombination. A mechanistic understanding of BRCA2 has been complicated by the embryonic lethality of mice bearing allelic knockouts of Brca2, and by variation in the DNA damage response in cells bearing BRCA2 deficiencies. It would be advantageous to develop...

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Identifiers

PMID: 17336596
DOI: 10.1016/j.dnarep.2007.01.007

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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