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Article

Mutant LRP6 Impairs Endothelial Cell Functions Associated with Familial Normolipidemic Coronary Artery Disease.

International journal of molecular sciences - 22 Jul 2016

Guo Jian, Li Yang, Ren Yi-Hong, Sun Zhijun, Dong Jie, Yan Han, Xu Yujun, Wang Dao Wen, Zheng Gu-Yan, Du Jie, Tian Xiao-Li

Abstract excerpt

Mutations in the genes low-density lipoprotein (LDL) receptor-related protein-6 (LRP6) and myocyte enhancer factor 2A (MEF2A) were reported in families with coronary artery disease (CAD). We intend to determine the mutational spectrum of these genes among hyperlipidemic and normolipidemic CAD families. Forty probands with early-onset CAD were recruited from 19 hyperlipidemic and 21 normolipidemic Chinese...

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Source

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Identifiers

PMID: 27455246
DOI: 10.3390/ijms17071173
PMCID: PMC4964544

Genes

CAD
LRP6

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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