Article
A second common variant in the methylenetetrahydrofolate reductase (MTHFR) gene and its relationship to MTHFR enzyme activity, homocysteine, and cardiovascular disease risk.
Journal of molecular medicine (Berlin, Germany) - 1 Sept 2001
Lievers K J, Boers G H, Verhoef P, den Heijer M, Kluijtmans L A, van der Put N M, Trijbels F J, Blom H J
Abstract excerpt
Molecular defects in genes encoding enzymes involved in homocysteine metabolism may account for mild hyperhomocysteinemia, an independent and graded risk factor for cardiovascular disease (CVD). We examined the relationship of two polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, the 677C-->T and 1298A-->C variants, to MTHFR activity, homocysteine concentrations, and risk of CVD in a...
Topics
- Adult
- Cardiovascular Diseases
- Fasting
- Female
- Genetic Predisposition to Disease
- Genotype
- Homocysteine
- Humans
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Middle Aged
- Mutation
- Oxidoreductases Acting on CH-NH Group Donors