Article
HIV infection of primary CD4+ Th2 cells, defined by expression of the chemoattractant receptor-homologous (CRTH2), induces a Th0 phenotype.
AIDS research and human retroviruses - 1 Feb 2007
Bahbouhi Bouchaib, Landay Alan, Tenorio Allan, Al-Harthi Lena
Abstract excerpt
The association between HIV, cytokine profile, and disease progression is controversial. In this study, we evaluated whether HIV infection of a primary T helper-like type 2 cytokine (Th2) cell subset augments their cytokine profile. We utilized the CRTH2 (chemoattractant receptor-homologous) marker to identify CD4+ Th2 cells. Approximately 2-4% of CD4+ T cells are CRTH2+. CRTH2+ expression is confirmed to...
Topics
- Antigens, CD
- CD4-Positive T-Lymphocytes
- Cells, Cultured
- HIV
- HIV Infections
- HLA-DR Antigens
- Humans
- Interferon-gamma
- Interleukin-4
- Phenotype
- Receptors, Immunologic
- Receptors, Prostaglandin
- T-Lymphocyte Subsets
- Th2 Cells
- Up-Regulation
- Virus Replication