Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals.

doi:10.1126/science.8023143

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Article

Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals.

Science (New York, N.Y.) - 8 Jul 1994

Graziosi C, Pantaleo G, Gantt K R, Fortin J P, Demarest J F, Cohen O J, Sékaly R P, Fauci A S

Abstract excerpt

A switch from a T helper 1 (TH1) cytokine phenotype to a TH2 phenotype has been proposed as a critical element in the progression of human immunodeficiency virus (HIV) disease. Here, constitutive cytokine expression was analyzed in unfractionated and sorted cell populations isolated from peripheral blood and lymph nodes of HIV-infected individuals at different stages of disease. Expression of interleukin-2 (IL-2)...

Topics

Apoptosis
CD8 Antigens
Cell Separation
Cross-Sectional Studies
HIV Infections
Humans
Interferon-gamma
Interleukin-10
Interleukin-2
Interleukin-4
Interleukins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Longitudinal Studies

Lymph Nodes

Lymphocyte Activation

Phenotype

T-Lymphocyte Subsets

T-Lymphocytes, Helper-Inducer

Source

Open in PubMed

Identifiers

PMID: 8023143
DOI: 10.1126/science.8023143

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8023143-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals.PMID 8023143Read ↗

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