Article
Ability of HIV to promote a TH1 to TH0 shift and to replicate preferentially in TH2 and TH0 cells.
Science (New York, N.Y.) - 8 Jul 1994
Maggi E, Mazzetti M, Ravina A, Annunziato F, de Carli M, Piccinni M P, Manetti R, Carbonari M, Pesce A M, del Prete G
Abstract excerpt
Both interferon gamma (IFN-gamma) produced by T helper 1 (TH1) lymphocytes and interleukin-4 (IL-4) produced by TH2 lymphocytes were reduced in either bulk circulating mononuclear cells or mitogen-induced CD4+ T cell clones from the peripheral blood of individuals infected with human immunodeficiency virus (HIV). There was a preferential reduction in clones producing IL-4 and IL-5 in the advanced phases of...
Topics
- Acquired Immunodeficiency Syndrome
- Cell Line
- Cells, Cultured
- HIV
- HIV Infections
- HIV Seropositivity
- Humans
- Immunologic Memory
- Interferon-gamma
- Interleukin-4
- Interleukin-5