Article
Evaluation of three canine gamma-crystallins (CRYGB, CRYGC, and CRYGS) as candidates for hereditary cataracts in the dachshund.
Molecular vision - 31 Jan 2007
Müller Christina, Wöhlke Anne, Distl Ottmar
Abstract excerpt
PURPOSE: We analyzed the gamma-crystallin genes CRYGB, CRYGC, and CRYGS in the dog and tested single nucleotide polymorphisms (SNPs) for linkage and association with primary noncongenital cataract (CAT) in the dachshund, a popular dog breed. The crystallin genes may be involved in the pathogenesis of canine CAT as shown in humans and mice. METHODS: We sequenced all exons and their flanking intronic regions of the...
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