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Article

An LMNA variant is associated with dyslipidemia and insulin resistance in the Japanese.

Metabolism: clinical and experimental - 1 Aug 2002

Murase Yuko, Yagi Kunimasa, Katsuda Yuko, Asano Akimichi, Koizumi Junji, Mabuchi Hiroshi

Abstract excerpt

Nuclear lamins A and C are encoded by LMNA and are present in terminally differentiated cells. Rare mutations in LMNA were shown to cause familial partial lipodystrophy, a syndrome characterized by regional loss of adipose tissue, glucose intolerance, and dyslipidemia, making LMNA a candidate gene for insulin-resistant diabetes. The aim of this study was to investigate whether genetic variation in LMNA can...

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Share to Hyperlipidemias
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12145775
DOI: 10.1053/meta.2002.34030

Genes

LMNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

An LMNA variant is associated with dyslipidemia and insulin resistance in the Japanese.PMID 12145775Read ↗

Association of LMNA 1908C/T polymorphism with cerebral vascular disease and diabetic nephropathy in Japanese men with type 2 diabetes.Semantic proximity Read ↗

Association between nuclear lamin A/C R482Q mutation and partial lipodystrophy with hyperinsulinemia, dyslipidemia, hypertension, and diabetes.Semantic proximity Read ↗

Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects.Semantic proximity Read ↗

Analysis of the lamin A/C gene as a candidate for type II diabetes susceptibility in Pima Indians.Semantic proximity Read ↗

Lamin A/C polymorphisms, type 2 diabetes, and the metabolic syndrome: case-control and quantitative trait studies.Semantic proximity Read ↗

Familial partial lipodystrophy associated with the heterozygous LMNA mutation 1445G>A (Arg482Gln) in a Polish family.Semantic proximity Read ↗

Genotype of the LMNA 1908C>T variant is associated with generalized obesity in Asian Indians in North India.Semantic proximity Read ↗

Atypical generalized lipoatrophy and severe insulin resistance due to a heterozygous LMNA p.T10I mutation.Semantic proximity Read ↗

Dyslipemia in familial partial lipodystrophy caused by an R482W mutation in the LMNA gene.Semantic proximity Read ↗

Common variation in LMNA increases susceptibility to type 2 diabetes and associates with elevated fasting glycemia and estimates of body fat and height in the general population: studies of 7,495 Danish whites.Semantic proximity Read ↗

The heterozygous LMNA mutation p.R471G causes a variable phenotype with features of two types of familial partial lipodystrophy.Semantic proximity Read ↗

Genetic variation in LMNA modulates plasma leptin and indices of obesity in aboriginal Canadians.Semantic proximity Read ↗

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