Article
Genetic association analysis of LARS2 with type 2 diabetes.
Diabetologia - 1 Jan 2010
Reiling E, Jafar-Mohammadi B, van 't Riet E, Weedon M N, van Vliet-Ostaptchouk J V, Hansen T, Saxena R, van Haeften T W, Arp P A, Das S, Nijpels G, Groenewoud M J, van Hove E C, Uitterlinden A G, Smit J W A, Morris A D, Doney A S F, Palmer C N A, Guiducci C, Hattersley A T, Frayling T M, Pedersen O, Slagboom P E, Altshuler D M, Groop L, Romijn J A, Maassen J A, Hofker M H, Dekker J M, McCarthy M I, 't Hart L M
Abstract excerpt
AIMS/HYPOTHESIS: LARS2 has been previously identified as a potential type 2 diabetes susceptibility gene through the low-frequency H324Q (rs71645922) variant (minor allele frequency [MAF] 3.0%). However, this association did not achieve genome-wide levels of significance. The aim of this study was to establish the true contribution of this variant and common variants in LARS2 (MAF > 5%) to type 2 diabetes risk....
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