Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations of the mouse ELMO domain containing 1 gene (Elmod1) link small GTPase signaling to actin cytoskeleton dynamics in hair cell stereocilia.

PloS one - 1 Jan 2012

Johnson Kenneth R, Longo-Guess Chantal M, Gagnon Leona H

Abstract excerpt

Stereocilia, the modified microvilli projecting from the apical surfaces of the sensory hair cells of the inner ear, are essential to the mechanoelectrical transduction process underlying hearing and balance. The actin-filled stereocilia on each hair cell are tethered together by fibrous links to form a highly patterned hair bundle. Although many structural components of hair bundles have been identified, little...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actin Cytoskeleton
Share to Cochlea
Share to Deafness

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTPase-Activating Proteins

Share to Hair Cells, Auditory

Share to Mice, Mutant Strains

Share to Monomeric GTP-Binding Proteins

Share to Receptors, Immunologic

Source

Open in PubMed Open full text

Identifiers

PMID: 22558334
DOI: 10.1371/journal.pone.0036074
PMCID: PMC3338648

Genes

ELMOD1
ELMOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations of the mouse ELMO domain containing 1 gene (Elmod1) link small GTPase signaling to actin cytoskeleton dynamics in hair cell stereocilia.PMID 22558334Read ↗

Defects in whirlin, a PDZ domain molecule involved in stereocilia elongation, cause deafness in the whirler mouse and families with DFNB31.Semantic proximity Read ↗

Pathophysiology of human hearing loss associated with variants in myosinsSemantic proximity Read ↗

Actin in hair cells and hearing loss.Semantic proximity Read ↗

Alström Syndrome protein ALMS1 localizes to basal bodies of cochlear hair cells and regulates cilium-dependent planar cell polaritySemantic proximity Read ↗

β-Actin and γ-Actin Are Each Dispensable for Auditory Hair Cell Development But Required for Stereocilia MaintenanceSemantic proximity Read ↗

Regionalized protein localization domains in the zebrafish hair cell kinociliumSemantic proximity Read ↗

The molecular architecture of the inner ear.Semantic proximity Read ↗

Usherin, the defective protein in Usher syndrome type IIA, is likely to be a component of interstereocilia ankle links in the inner ear sensory cellsSemantic proximity Read ↗

An alteration in ELMOD3, an Arl2 GTPase-activating protein, is associated with hearing impairment in humans.Semantic proximity Read ↗

Planar cell polarity in the inner ear.Semantic proximity Read ↗

The deaf mouse mutant whirler suggests a role for whirlin in actin filament dynamics and stereocilia development.Semantic proximity Read ↗

Deficiency of angulin-2/ILDR1, a tricellular tight junction-associated membrane protein, causes deafness with cochlear hair cell degeneration in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.