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Article

Acetylcholine receptor channel subtype directs the innervation pattern of skeletal muscle.

EMBO reports - 1 Jun 2005

Koenen Michael, Peter Christoph, Villarroel Alfredo, Witzemann Veit, Sakmann Bert

Abstract excerpt

Acetylcholine receptors (AChRs) mediate synaptic transmission at the neuromuscular junction, and structural and functional analysis has assigned distinct functions to the fetal (alpha2beta(gamma)delta) and adult types of AChR (alpha2beta(epsilon)delta). Mice lacking the epsilon-subunit gene die prematurely, showing that the adult type is essential for maintenance of neuromuscular synapses in adult muscle. It has...

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Source

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Identifiers

PMID: 15905852
DOI: 10.1038/sj.embor.7400429
PMCID: PMC1369094

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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