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Article

Frequency-dependent response of the vascular endothelium to pulsatile shear stress

23 Feb 2007

Abstract excerpt

As a result of the complex blood flow patterns that occur in the arterial tree, certain regions of the vessel wall experience fluctuations in shear stress that are dominated by harmonic frequencies higher than the heart rate (11). To assess whether variations in frequency affect endothelial gene expression, the gene expression patterns of cultured porcine aortic endothelium exposed to three sinusoidal waveforms...

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PMID: 17322417
DOI: 10.1152/ajpheart.01087.2006

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