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Article

Structure of the N-terminal domain of human CEACAM1: binding target of the opacity proteins during invasion ofNeisseria meningitidisandN. gonorrhoeae

19 Aug 2006

Abstract excerpt

CEACAM1 is a cellular adhesion molecule whose protein expression is down-regulated in several carcinomas and which also contributes to the pathogenicity of Neisseria by acting as a receptor for Opa proteins. The crystal structure of the N-terminal (D1) domain of human CEACAM1 has been determined at 2.2 Angstrom resolution. The structure shows several differences compared with a lower resolution model of the same...

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PMID: 16929097
DOI: 10.1107/s0907444906020737

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