Article
Clostridium difficile toxin B disrupts the barrier function of T84 monolayers.
Gastroenterology - 1 Feb 1992
Hecht G, Koutsouris A, Pothoulakis C, LaMont J T, Madara J L
Abstract excerpt
The contribution of toxin B to Clostridium difficile-associated infection is undefined. Toxin B induces dramatic phenotypic alterations (cytotoxic effects) in cultured mesenchymal and nonintestinal epithelial cells, yet its effects on intestinal epithelial cells are not clearly understood. The alterations induced by toxin B in nonintestinal cells appear to be secondary to toxin-induced redistribution of...
Topics
- Actins
- Bacterial Proteins
- Bacterial Toxins
- Cells, Cultured
- Clostridioides difficile
- Cycloheximide
- Cytotoxins
- Epithelium
- Humans
- Intestinal Mucosa
- L-Lactate Dehydrogenase
- Phenotype