Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Variant toxin B and a functional toxin A produced by Clostridium difficile C34.

FEMS microbiology letters - 1 May 2001

Mehlig M, Moos M, Braun V, Kalt B, Mahony D E, von Eichel-Streiber C

Abstract excerpt

A particular property of Clostridium difficile strain C34 is an insertion of approximately 2 kb in the tcdA-C34 gene that does not hinder expression of a fully active TcdA-C34 molecule. Intoxication with TcdA-C34 induced an arborized appearance in eukaryotic cells (D-type cytopathic effect); intoxication with TcdB-C34 induced a spindle-like appearance of cells (S-type cytopathic effect). Inactivation of GTPases...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Toxins
Share to CHO Cells
Share to Clostridioides difficile

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytotoxins

Share to DNA Transposable Elements

Share to Enterotoxins

Share to Microscopy, Electron, Scanning

Source

Identifiers

PMID: 11430410
DOI: 10.1111/j.1574-6968.2001.tb10638.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variant toxin B and a functional toxin A produced by Clostridium difficile C34.PMID 11430410Read ↗

Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities.Semantic proximity Read ↗

Toxin B is essential for virulence of Clostridium difficile.Semantic proximity Read ↗

Clostridium difficile Toxins A and B: Insights into Pathogenic Properties and Extraintestinal EffectsSemantic proximity Read ↗

The role of toxin A and toxin B in Clostridium difficile-associated diseaseSemantic proximity Read ↗

Identification of an Essential Region for Translocation of Clostridium difficile Toxin B.Semantic proximity Read ↗

Clostridium difficile Toxins TcdA and TcdB Cause Colonic Tissue Damage by Distinct MechanismsSemantic proximity Read ↗

Truncation in the tcdC region of the Clostridium difficile PathLoc of clinical isolates does not predict increased biological activity of Toxin B or Toxin A.Semantic proximity Read ↗

Characterization of a toxin A-negative, toxin B-positive strain of Clostridium difficileSemantic proximity Read ↗

The glucosyltransferase activity of C. difficile Toxin B is required for disease pathogenesisSemantic proximity Read ↗

Isolation of a fibroblast mutant resistant to Clostridium difficile toxins A and B.Semantic proximity Read ↗

Mutational analysis of the enzymatic domain of Clostridium difficile toxin B reveals novel inhibitors of the wild-type toxin.Semantic proximity Read ↗

A novel approach to generate a recombinant toxoid vaccine against Clostridium difficile.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.