Article
Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study.
Human molecular genetics - 1 Jul 2005
Newhouse Stephen J, Wallace Chris, Dobson Richard, Mein Charles, Pembroke Janine, Farrall Martin, Clayton David, Brown Morris, Samani Nilesh, Dominiczak Anna, Connell John M, Webster John, Lathrop G Mark, Caulfield Mark, Munroe Patricia B
Abstract excerpt
Mutations in the WNK1 gene cause Gordon's syndrome, a rare Mendelian form of hypertension. We assessed whether common WNK1 variants might also contribute to essential hypertension (EH), a multifactorial disorder affecting > 25% of the adult population worldwide. A panel of 19 single nucleotide polymorphisms (SNPs) spanning the gene was selected from public databases and was genotyped in 100 white European...
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