Article
DnIKK2-transfected dendritic cells induce a novel population of inducible nitric oxide synthase-expressing CD4+CD25- cells with tolerogenic properties.
Transplantation - 27 Feb 2007
Aiello Sistiana, Cassis Paola, Cassis Linda, Tomasoni Susanna, Benigni Ariela, Pezzotta Anna, Cavinato Regiane A, Cugini Daniela, Azzollini Nadia, Mister Marilena, Longaretti Lorena, Thomson Angus W, Remuzzi Giuseppe, Noris Marina
Abstract excerpt
BACKGROUND: We previously documented that rat bone marrow-derived dendritic cells (DCs), transfected with an adenovirus encoding a dominant negative form of IKK2 (dnIKK2), have impaired allostimulatory capacity and generate CD4 T cells with regulatory function. Here we investigate the potency, the phenotype, and the mechanism of action of dnIKK2-DC-induced regulatory cells and we evaluated their tolerogenic...
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