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Article

Membrane-bound IL-2 improves the expansion, survival, and phenotype of CAR Tregs and confers resistance to calcineurin inhibitors.

Frontiers in immunology - 1 Jan 2022

Kremer Jakob, Henschel Pierre, Simon Daniel, Riet Tobias, Falk Christine, Hardtke-Wolenski Matthias, Wedemeyer Heiner, Noyan Fatih, Jaeckel Elmar

Abstract excerpt

Background: Regulatory T cells (Tregs) play an important role in the maintenance of immune homeostasis and the establishment of immune tolerance. Since Tregs do not secrete endogenous IL-2, they are especially dependent on external IL-2. IL-2 deficiency leads to lower Treg numbers, instability of the Treg phenotype and loss of immune regulation. After organ transplantation, patients are treated with calcineurin...

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Identifiers

PMID: 36618378
DOI: 10.3389/fimmu.2022.1005582
PMCID: PMC9816406

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