Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD4+FoxP3+ regulatory T cells gradually accumulate in gliomas during tumor growth and efficiently suppress antiglioma immune responses in vivo.

International journal of cancer - 1 Jul 2007

Grauer Oliver M, Nierkens Stefan, Bennink Erik, Toonen Liza W J, Boon Louis, Wesseling Pieter, Sutmuller Roger P M, Adema Gosse J

Abstract excerpt

The suppressive activity of regulatory T cells (Treg) has been implicated as an important factor limiting immune mediated destruction of tumor cells. However, not much is known about the presence and function of Treg within tumors. Here we show in a syngeneic murine glioma model a time-dependent accumulation of CD4+FoxP3+ Treg in brain tumors. Further analysis revealed a time-dependent upregulation of CD25,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies
Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD8-Positive T-Lymphocytes

Share to Cell Separation

Share to Forkhead Transcription Factors

Share to Glioma

Share to Immunotherapy

Share to Interleukin-2 Receptor alpha Subunit

Source

Identifiers

PMID: 17315190
DOI: 10.1002/ijc.22607

Genes

CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD4+FoxP3+ regulatory T cells gradually accumulate in gliomas during tumor growth and efficiently suppress antiglioma immune responses in vivo.PMID 17315190Read ↗

Prolongation of survival following depletion of CD4+CD25+ regulatory T cells in mice with experimental brain tumors.Semantic proximity Read ↗

FOXP3+ Treg as a therapeutic target for promoting anti-tumor immunity.Semantic proximity Read ↗

Induced and natural regulatory T cells in human cancer.Semantic proximity Read ↗

Regulatory T cells converted from Th1 cells in tumors suppress cancer immunity via CD39Semantic proximity Read ↗

CD4+Foxp3- type 1 regulatory T cells in glioblastoma multiforme suppress T cell responses through multiple pathways and are regulated by tumor-associated macrophages.Semantic proximity Read ↗

Regulatory T cells promote glioma cell stemness through TGF-β–NF-κB–IL6–STAT3 signalingSemantic proximity Read ↗

Amplification of tumor-specific regulatory T cells following therapeutic cancer vaccines.Semantic proximity Read ↗

Increased intratumoral regulatory T cells are related to intratumoral macrophages and poor prognosis in hepatocellular carcinoma patients.Semantic proximity Read ↗

Providence of the CD25+ KIR+ CD127- FOXP3- CD8+ T-cell subset determines the dynamics of tumor immune surveillance.Semantic proximity Read ↗

Circulating T regulatory cells migration and phenotype in glioblastoma patients: an in vitro study.Semantic proximity Read ↗

CD25+ CD4+ regulatory T-cells in cancer.Semantic proximity Read ↗

Skin Melanoma Development in ret Transgenic Mice Despite the Depletion of CD25+Foxp3+ Regulatory T Cells in Lymphoid OrgansSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.