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Article

CD4+Foxp3- type 1 regulatory T cells in glioblastoma multiforme suppress T cell responses through multiple pathways and are regulated by tumor-associated macrophages.

The international journal of biochemistry & cell biology - 1 Dec 2016

Li Zhao, Liu Xiaobing, Guo Rongbin, Wang Pengfei

Abstract excerpt

CD4+Foxp3- type 1 regulatory T (Tr1) cells are potent producers of interleukin 10 (IL-10) and transforming growth factor beta (TGF-β), through which they suppress pathogenic inflammation and autoimmune responses. The role of Tr1 response in glioblastoma multiforme (GBM) is still unclear. Here, we examined the frequency, phenotype, induction mechanism, and function of Tr1 cells in GBM patients. Compared to healthy...

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PMID: 27644153
DOI: 10.1016/j.biocel.2016.09.013

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TNF

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