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Article

The genetic susceptibility to IgA nephropathy: a novel functional candidate gene for incomplete O-glycosylation of IgA1.

Kidney international - 1 Mar 2007

Narita I, Kaneko Y, Kondo D, Goto S, Sakatsume M, Gejyo F

Abstract excerpt

Incompleteness of O-glycosylation in the IgA1 hinge has been implicated as a central mechanism in the development of IgA nephropathy. Although underglycosylation was reported to be an acquired abnormality, genes for enzymes of O-glycosylation, such as C1GALT1, may be responsible for susceptibilit...

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Share to Galactosyltransferases
Share to Genetic Predisposition to Disease
Share to Glomerulonephritis, IGA

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Identifiers

PMID: 17315006
DOI: 10.1038/sj.ki.5002139

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17315006-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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