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Article

A phenomics approach in yeast links proton and calcium pump function in the Golgi.

Molecular biology of the cell - 1 Apr 2007

Yadav Jyoti, Muend Sabina, Zhang Yongqiang, Rao Rajini

Abstract excerpt

The Golgi-localized Ca2+- and Mn2+-transporting ATPase Pmr1 is important for secretory pathway functions. Yeast mutants lacking Pmr1 show growth sensitivity to multiple drugs (amiodarone, wortmannin, sulfometuron methyl, and tunicamycin) and ions (Mn2+ and Ca2+). To find components that function within the same or parallel cellular pathways as Pmr1, we identified genes that shared multiple pmr1 phenotypes. These...

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Identifiers

PMID: 17314395
DOI: 10.1091/mbc.e06-11-1049
PMCID: PMC1839000

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