Article
The Golgi Ca2+-ATPase KlPmr1p function is required for oxidative stress response by controlling the expression of the heat-shock element HSP60 in Kluyveromyces lactis.
Molecular biology of the cell - 1 Oct 2005
Uccelletti Daniela, Farina Francesca, Pinton Paolo, Goffrini Paola, Mancini Patrizia, Talora Claudio, Rizzuto Rosario, Palleschi Claudio
Abstract excerpt
The Golgi P-type Ca2+-ATPase, Pmr1p, is the major player for calcium homeostasis in yeast. The inactivation of KlPMR1 in Kluyveromyces lactis leads to high pleiotropic phenotypes that include reduced glycosylation, cell wall defects, and alterations of mitochondrial metabolism. In this article we found that cells lacking KlPmr1p have a morphologically altered mitochondrial network and that mitochondria (m) from...
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