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Article

Requirement of subunit co-assembly and ankyrin-G for M-channel localization at the axon initial segment.

Journal of cell science - 15 Mar 2007

Rasmussen Hanne B, Frøkjaer-Jensen Christian, Jensen Camilla S, Jensen Henrik S, Jørgensen Nanna K, Misonou Hiroaki, Trimmer James S, Olesen Søren-Peter, Schmitt Nicole

Abstract excerpt

The potassium channel subunits KCNQ2 and KCNQ3 are believed to underlie the M current of hippocampal neurons. The M-type potassium current plays a key role in the regulation of neuronal excitability; however, the subcellular location of the ion channels underlying this regulation has been controversial. We report here that KCNQ2 and KCNQ3 subunits are localized to the axon initial segment of pyramidal neurons of...

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Source

Identifiers

PMID: 17311847
DOI: 10.1242/jcs.03396

Genes

KCNQ2
KCNQ3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Requirement of subunit co-assembly and ankyrin-G for M-channel localization at the axon initial segment.PMID 17311847Read ↗

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Ankyrin-G and Its Binding Partners in Neurons: Orchestrating the Molecular Structure of the Axon Initial SegmentSemantic proximity Read ↗

Calmodulin orchestrates the heteromeric assembly and the trafficking of KCNQ2/3 (Kv7.2/3) channels in neurons.Semantic proximity Read ↗

Pathophysiological Roles of Abnormal Axon Initial Segments in Neurodevelopmental DisordersSemantic proximity Read ↗

A neuron type-specific microexon in <i>Ank3</i> /ankyrin-G modulates calcium activity and neuronal excitabilitySemantic proximity Read ↗

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The Role of the Carboxyl Terminus Helix C-D Linker in Regulating KCNQ3 K+ Current Amplitudes by Controlling Channel Trafficking.Semantic proximity Read ↗

An ankyrinG-binding motif is necessary and sufficient for targeting Nav1.6 sodium channels to axon initial segments and nodes of Ranvier.Semantic proximity Read ↗

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