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Article

KCNQ2 is a nodal K+ channel.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 4 Feb 2004

Devaux Jérôme J, Kleopa Kleopas A, Cooper Edward C, Scherer Steven S

Abstract excerpt

Mutations in the gene encoding the K+ channel KCNQ2 cause neonatal epilepsy and myokymia, indicating that KCNQ2 regulates the excitability of CNS neurons and motor axons, respectively. We show here that KCNQ2 channels are functional components of axon initial segments and nodes of Ranvier, colocalizing with ankyrin-G and voltage-dependent Na+ channels throughout the CNS and PNS. Retigabine, which opens KCNQ...

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Share to Spinal Cord
Share to Potassium Channels, Voltage-Gated
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 14762142
DOI: 10.1523/JNEUROSCI.4512-03.2004
PMCID: PMC6793582

Genes

KCNQ2
KCNQ3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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KCNQ2 is a nodal K+ channel.PMID 14762142Read ↗

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