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Article

Prevalence and evolutionary origins of autoimmune susceptibility alleles in natural mouse populations.

Genes and immunity - 1 Jan 2008

Limaye N, Belobrajdic K A, Wandstrat A E, Bonhomme F, Edwards S V, Wakeland E K

Abstract excerpt

The evolutionary origin of genetic diversity in the SLAM/CD2 gene cluster, implicated in autoimmune lupus susceptibility in mice, was investigated by sequence analysis of exons from six members of the cluster in 48 wild mouse samples derived from the global mouse population. A total of 80 coding region SNPs were identified among the six genes analyzed, indicating that this gene cluster is highly polymorphic in...

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Identifiers

PMID: 18094711
DOI: 10.1038/sj.gene.6364446

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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