Article
Functional complementation of a yeast knockout strain by Schistosoma mansoni Rho1 GTPase in the presence of caffeine, an agent that affects mutants defective in the protein kinase C signal transduction pathway.
Memorias do Instituto Oswaldo Cruz - 1 Sept 2006
Aguiar Pedro H N de, Santos Débora N, Lobo Francisco P, Santos Túlio M, Macedo Andréa M, Pena Sérgio D J, Machado Carlos R, Franco Glória R
Abstract excerpt
In a previous study, the Schistosoma mansoni Rho1 protein was able to complement Rho1 null mutant Saccharomyces cerevisiae cells at restrictive temperatures and under osmotic stress (low calcium concentration) better than the human homologue (RhoA). It is known that under osmotic stress, the S. cerevisiae Rho1 triggers two distinct pathways: activation of the membrane 1,3-beta-glucan synthase enzymatic complex...
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