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Article

Conditional lethality of a yeast strain expressing human RHOA in place of RHO1.

Proceedings of the National Academy of Sciences of the United States of America - 27 Sept 1994

Qadota H, Anraku Y, Botstein D, Ohya Y

Abstract excerpt

The yeast RHO1 GTPase, which has 72% amino acid sequence identity with its human counterpart, RHOA, is essential for growth, although the reason has not been investigated. We report here that yeast strains that rely solely on expression of human RHOA in place of RHO1 are able to grow at 23 degrees C but grow neither at 37 degrees C nor in the presence of 300 mM CaCl2 even at 23 degrees C. Measurements of...

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Identifiers

PMID: 7937763
DOI: 10.1073/pnas.91.20.9317
PMCID: PMC44803

Genes

RHOA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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