Article
Schistosoma mansoni: Heterologous complementation of a yeast null mutant by SmRbx, a protein similar to a RING box protein involved in ubiquitination.
Experimental parasitology - 1 Aug 2007
Santos Débora N, Aguiar Pedro H N, Lobo Francisco P, Mourão Marina M, Tambor José H M, Valadão Analina F, Vilas-Boas Adlane, Nobrega Francisco G, LoVerde Philip T, Macedo Andréa M, Pena Sérgio D J, Machado Carlos R, Franco Glória R
Abstract excerpt
The SCF (Skp1-Cul1-F-box) complex is one of the several E3 ligase enzymes and it catalyzes protein ubiquitination and degradation by the 26S proteasome. Rbx1 is a member of the SCF complex in humans and HRT1 is its yeast orthologue. A cDNA encoding a Schistosoma mansoni Rbx1 homolog was cloned and functionally characterized. Heterologous functional complementation in yeast showed that the worm SmRbx gene was able...
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