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Article

Genome-wide association study implicates testis-sperm specific FKBP6 as a susceptibility locus for impaired acrosome reaction in stallions.

PLoS genetics - 1 Jan 2012

Raudsepp Terje, McCue Molly E, Das Pranab J, Dobson Lauren, Vishnoi Monika, Fritz Krista L, Schaefer Robert, Rendahl Aaron K, Derr James N, Love Charles C, Varner Dickson D, Chowdhary Bhanu P

Abstract excerpt

Impaired acrosomal reaction (IAR) of sperm causes male subfertility in humans and animals. Despite compelling evidence about the genetic control over acrosome biogenesis and function, the genomics of IAR is as yet poorly understood, providing no molecular tools for diagnostics. Here we conducted Equine SNP50 Beadchip genotyping and GWAS using 7 IAR-affected and 37 control Thoroughbred stallions. A significant...

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Identifiers

PMID: 23284302
DOI: 10.1371/journal.pgen.1003139
PMCID: PMC3527208

Genes

FKBP6

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