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Article

Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization.

Proceedings of the National Academy of Sciences of the United States of America - 27 Feb 2007

García-Alvarez Begoña, de Cárcer Guillermo, Ibañez Sonia, Bragado-Nilsson Elisabeth, Montoya Guillermo

Abstract excerpt

Polo-like kinase (Plk1) is crucial for cell cycle progression through mitosis. Here we present the molecular and structural mechanisms that regulate the substrate recognition of Plk1 and influence its centrosomal localization and activity. Our work shows that Plk1 localization is controlled not only by the polo box domain (PBD); remarkably, the kinase domain is also involved in Plk1 targeting mechanism to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17307877
DOI: 10.1073/pnas.0609131104
PMCID: PMC1805623

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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