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Article

The G226A mutant of Gs alpha highlights the requirement for dissociation of G protein subunits.

The Journal of biological chemistry - 15 Jan 1992

Lee E, Taussig R, Gilman A G

Abstract excerpt

Adenylylcyclase cannot be activated by hormones or guanine nucleotide analogs in membranes from cells that express the G226A mutant form Gs alpha instead of the wild-type protein. The mutant Gs alpha protein appears incapable of undergoing the conformational change necessary for guanine nucleotide-induced dissociation of the G protein alpha subunit from the beta gamma subunit complex (Miller, R.T., Masters, S.B.,...

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PMID: 1730644

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