Article
Vaccinia virus double-stranded RNA-binding protein E3 does not interfere with siRNA-mediated gene silencing in mammalian cells.
Virus research - 1 Jun 2007
Lantermann Markus, Schwantes Astrid, Sliva Katja, Sutter Gerd, Schnierle Barbara S
Abstract excerpt
Vaccinia virus (VACV) evolved several strategies to evade antiviral cellular defence. The vaccinia virus E3 protein for example binds and sequesters double stranded RNA (dsRNA) and counteracts interferon action. We were interested to find out whether and to what extend E3 interferes with RNA sile...
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