Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Vaccinia virus E3 protein prevents the antiviral action of ISG15.

PLoS pathogens - 4 Jul 2008

Guerra Susana, Cáceres Ana, Knobeloch Klaus-Peter, Horak Ivan, Esteban Mariano

Abstract excerpt

The ubiquitin-like modifier ISG15 is one of the most predominant proteins induced by type I interferons (IFN). In this study, murine embryo fibroblast (MEFs) and mice lacking the gene were used to demonstrate a novel role of ISG15 as a host defense molecule against vaccinia virus (VACV) infection. In MEFs, the growth of replication competent Western Reserve (WR) VACV strain was affected by the absence of ISG15,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chlorocebus aethiops
Share to Cricetinae
Share to Disease Susceptibility

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Silencing

Share to RNA-Binding Proteins

Share to RNA, Small Interfering

Share to Ubiquitins

Share to Vaccinia virus

Source

Open in PubMed Open full text

Identifiers

PMID: 18604270
DOI: 10.1371/journal.ppat.1000096
PMCID: PMC2434199

Genes

ISG15

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Vaccinia virus E3 protein prevents the antiviral action of ISG15.PMID 18604270Read ↗

ISG15 is required for the dissemination of <i>Vaccinia virus</i> extracellular virionsSemantic proximity Read ↗

ISG15 is counteracted by vaccinia virus E3 protein and controls the proinflammatory response against viral infection.Semantic proximity Read ↗

Novel Mode of ISG15-Mediated Protection against Influenza A Virus and Sendai Virus in MiceSemantic proximity Read ↗

ISG15 Modulates Type I Interferon Signaling and the Antiviral Response during Hepatitis E Virus ReplicationSemantic proximity Read ↗

ISG15 Is Required for the Dissemination of Vaccinia Virus Extracellular VirionsSemantic proximity Read ↗

Consecutive Inhibition of ISG15 Expression and ISGylation by Cytomegalovirus RegulatorsSemantic proximity Read ↗

IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis virusesSemantic proximity Read ↗

ISGylation in Innate Antiviral Immunity and Pathogen Defense Responses: A ReviewSemantic proximity Read ↗

ISG15 driven cellular responses to virus infectionSemantic proximity Read ↗

ISG15 facilitates cellular antiviral response to dengue and west nile virus infection in vitroSemantic proximity Read ↗

Ubiquitin-like Molecule ISG15 Acts as an Immune Adjuvant to Enhance Antigen-specific CD8 T-cell Tumor Immunity.Semantic proximity Read ↗

ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.