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Vaccinia Virus K1L and C7L Inhibit Antiviral Activities Induced by Type I Interferons

6 Aug 2009

Abstract excerpt

Cellular tropism of vaccinia virus (VACV) is regulated by host range genes, including K1L, C7L, and E3L. While E3L is known to support viral replication by antagonizing interferon (IFN) effectors, including PKR, the exact functions of K1L and C7L are unclear. Here, we show that K1L and C7L can also inhibit antiviral effectors induced by type I IFN. In human Huh7 and MCF-7 cells, a VACV mutant lacking both K1L and...

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Identifiers

PMID: 19656868
DOI: 10.1128/jvi.01260-09

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