[Classification of mutations in the insulin receptor gene].

Article

[Classification of mutations in the insulin receptor gene].

Nihon rinsho. Japanese journal of clinical medicine - 1 Oct 1994

Kadowaki T

Abstract excerpt

Mutations in the insulin receptor gene can cause insulin resistance by interfering with a step (s) in the life cycle of the insulin receptor. These steps include biosynthesis, posttranslational modifications and transport to plasma membrane, ligand binding, trans membrane signaling, and endocytos...

Topics

Biological Transport
Humans
Insulin
Insulin Resistance
Mutation
Protein Processing, Post-Translational
Protein-Tyrosine Kinases
Receptor, Insulin

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