[Classification of mutations in the insulin receptor gene].

Abstract excerpt

Mutations in the insulin receptor gene can cause insulin resistance by interfering with a step (s) in the life cycle of the insulin receptor. These steps include biosynthesis, posttranslational modifications and transport to plasma membrane, ligand binding, trans membrane signaling, and endocytosis, recycling and degradation. Mutations are functionally classified into five classes: mutations that decrease the...

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