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Article

A new assay for invasion of HeLa 229 cells by Bordetella pertussis: effects of inhibitors, phenotypic modulation, and genetic alterations.

Infection and immunity - 1 Aug 1990

Lee C K, Roberts A L, Finn T M, Knapp S, Mekalanos J J

Abstract excerpt

Invasion and intracellular survival of Bordetella pertussis in HeLa 229 cells was studied by a new assay that utilizes polymyxin B instead of gentamicin to rapidly kill extracellular organisms. Invasion measured by this assay was time and temperature dependent and was inhibited by the microfilament drug cytochalasin D. The invasion process was also dependent on a functional vir locus (also known as bvg), the...

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Identifiers

PMID: 2370104
DOI: 10.1128/iai.58.8.2516-2522.1990
PMCID: PMC258849

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