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Article

Mutations in the linker region of BvgS abolish response to environmental signals for the regulation of the virulence factors in Bordetella pertussis.

Gene - 2 Dec 1994

Manetti R, Aricò B, Rappuoli R, Scarlato V

Abstract excerpt

Expression of virulence factors of Bordetella pertussis is coordinately regulated by the products of the bvg locus, which codes for a sensory protein (BvgS) and a positive regulator of transcription (BvgA), a pair in the family of bacterial 'two-component' regulators. Transcription of the bvg-regulated promoters is repressed by modulating environmental factors such as 50 mM MgSO4, 10 mM nicotinic acid (NA) or low...

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PMID: 7959037
DOI: 10.1016/0378-1119(94)90870-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Mutations in the linker region of BvgS abolish response to environmental signals for the regulation of the virulence factors in Bordetella pertussis.PMID 7959037Read ↗

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The BvgAS Regulon of Bordetella pertussisSemantic proximity Read ↗

The BvgS PAS domain: an independent sensory perception module in the <i>Bordetella</i> BvgAS phosphorelaySemantic proximity Read ↗

Structural and genetic analysis of the bvg locus in Bordetella species.Semantic proximity Read ↗

A mutation in the Bordetella bronchiseptica bvgS gene results in reduced virulence and increased resistance to starvation, and identifies a new class of Bvg-regulated antigens.Semantic proximity Read ↗

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