Article
Mutations in the linker region of BvgS abolish response to environmental signals for the regulation of the virulence factors in Bordetella pertussis.
Gene - 2 Dec 1994
Manetti R, Aricò B, Rappuoli R, Scarlato V
Abstract excerpt
Expression of virulence factors of Bordetella pertussis is coordinately regulated by the products of the bvg locus, which codes for a sensory protein (BvgS) and a positive regulator of transcription (BvgA), a pair in the family of bacterial 'two-component' regulators. Transcription of the bvg-regulated promoters is repressed by modulating environmental factors such as 50 mM MgSO4, 10 mM nicotinic acid (NA) or low...
Topics
- Amino Acid Sequence
- Bacterial Proteins
- Bordetella pertussis
- Gene Expression Regulation, Bacterial
- Molecular Sequence Data
- Mutation
- Transcription Factors
- Transcription, Genetic
- Virulence