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Article

The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development.

The EMBO journal - 7 Mar 2007

Grose Richard, Fantl Vera, Werner Sabine, Chioni Athina-Myrto, Jarosz Monika, Rudling Robert, Cross Barbara, Hart Ian R, Dickson Clive

Abstract excerpt

The epithelial isoform of fibroblast growth factor receptor 2 (Fgfr2b) is essential for embryogenesis, and Fgfr2b-null mice die at birth. Using Cre-Lox transgenics to delete Fgfr2b in cells expressing keratin 5, we show that mice lacking epidermal Fgfr2b survive into adulthood but display striking abnormalities in hair and sebaceous gland development. Epidermal hyperthickening develops with age, and 10% of mutant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17304214
DOI: 10.1038/sj.emboj.7601583
PMCID: PMC1817631

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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